نویسندگان
Hamid Reza Alizadeh-Otaghvar Gholam Reza Khamisipour , Ali Akbar Pourfathollah , Masoud Soleimani , Mehdi Fourouzandeh Moghaddam , Mehrdad Norouzinia , Said Kavyani , Kamran Ali Moghaddam , Gholam Reza Heydari
تاریخ انتشار
2014
ژورنال
Iranian South Medical Journal
جلد
17
نسخه
4
صفحات
506-516
توضیح
Background
Epigenetic reprogramming of somatic cells into embryonic stem cells has attracted much attention, because of the potential for stem cell transplantation and compatibility with recipient. However, the therapeutic application of either nuclear transfer or nuclear fusion of somatic cell has been hindered by technical complications as well as ethical objections. Recently, a new method is reported whereby ectopic expression of embryonic specific transcription factors was shown to induce fibroblasts to become embryonic like SCs (induced pluripotent stem cells). A major limitation of this method is the use of potentially harmful genome integrating viruses such as reto-or lentivirus. The main aim of this investigation was generation of human hematopoietic stem cells from induced fibroblasts by safe adenovectors carrying embryonically active genes.