نویسندگان
ALIZADEH H.R. MIRMALEK S.A., TIRGARI F.
تاریخ انتشار
2005
ژورنال
IRANIAN JOURNAL OF SURGERY
جلد
13
نسخه
34
صفحات
48 To 54
توضیح
Background
BREAST CARCINOMA is near (32%) of all and the second cause of malignacies related deaths in woman and one of the main investigated subjects for prognostic and predictive factors. One of these factors is Human Epidermal Growth Factor Receptor-2 (HER-2), if found in normal stroma could be predisposing to carcinoma.
Study Design
We decided to evaluate the prevalence of HER-2 in benign tissue around breast tumors and gathered 106 among 2167 BREAST CARCINOMA cases in Cancer Institute since 2002-2004. A retrospective descriptive analysis was conducted and besides the main subject, correlation between the age and pathologic type was considered.
Finding
We found 58% HER-2 positive in the tumor of our cases and 39% of them had also positive HRE-2 in their normal breast tissue around tumor compared with 32% negative HER-2 in tumor with 12% negative normal breast tissue. More than half (% 66.4) of the cases had 41-60 years old in most common type of malignancy was invasive ductal.
Conclusion